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Haibin WANG, Ph. D.

Molecular basis of preimplantation embryo development and embryo-uterine interactions during implantation, decidualization and placentation with respect to growth factors, cytokines and developmental genes


Co-workers: Bingyan Wang, Shuangbo Kong, Hangxiao Zhang, Bo He, Tongtong Cui, Guixian Liang, Haili Bao, Qiliang Xin(China Agriculture University), Jingtao Qiu(China Agriculture University), Chan Zhou(China Agriculture University), Zhangli Ni(China Agriculture University).

• WANG Group website

 

  Successful implantation is the result of reciprocal interactions between the implantation-competent blastocyst and receptive uterus. Although a wealth of information is available, definitive molecular mechanisms underlying the embryo-uterine crosstalk during implantation and decidualization remain largely unknown. The exploration of various aspects and molecules associated with these events, a comprehensive understanding of the reproductive pathology process will improve the methods of treating diseases. Although our team was newly founded in 2008, the dreams and passion for knowing the unknown had been seeded in our mind, like the American famous scientist Glenn Theodore Seaborg said:“ the scientific discoverer is the first to see or to know a really new things: she/he is the locksmith of the centuries who has finally fashioned a key to open the door to one of natures' secrets”. The pursuit of science is a wonderful world if you love it. You can be part of it.



The molecular network for pregnancy establishment and maintenance  



The spatiotemporal mRNA expression of Wnt signaling members during the mouse periimplantation uteri  



The tetraploid complement approach for demonstrating the indispensable role Fzd5 mediating Wnt signaling during the placental chorion morphogenesis  

 

 

Plain English:
  Molecular basis of preimplantation embryo development and embryo-uterine interactions during implantation, decidualization and placentation with respect to growth factors, cytokines and developmental genes

 

Selected publications:

  1. Tu Z, Wang Q, Cui T, Wang J , Ran H , Bao H, Lu J, Wang B, Lydon JP, DeMayo F, Zhang S, Kong S, Wu X and Wang H*. Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice. Cell Death Differ. 23(1):169-81,2016.
  2. Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, John P Lydon, Francesco DeMayo, Warren S. Pear, Hua H, Lin H, Li L, Wang H, Wang Y, Li B, Chen Q, Duan E, Wang H*. Uterine Rbpj is required for embryo-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms. Cell Res.24(8):925-942,2014.
  3. Lu J, Zhang S, Nakano N, Simmons DG, Wang S, Wang Q, Kong S, Shen L, Wang W, Wang B, Wang HM, Wang YL, van Es JH, Clevers H, Leone G, Cross JC, Wang H*. A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biology. 11(4), e1001536,2013.
  4. Zhang S, Lin H, Kong S, Wang S, Wang H, Wang H*, Armant DR* (Co-correspondence)..Physiological and molecular determinants of embryo implantation. Mol Aspects Med. 34,939-980,2013.
  5. Lim H & Wang H* (Co-correspondence). Uterine disorders and pregnancy complications: insights from mouse models. J CIin Invest. 120(4), 1004-15, 2010.



DKK1 overexpression dampened the activity of Wnt-βcatenin signaling in the blastocyst trophectoderm