Researchers identify an endogenous metabolite that promotes multiple tissue regeneration and delays aging [2022-02-07]
Regeneration is an important process of rejuvenating or replacing damaged, diseased, or aged tissues. Regenerative capacity declines with evolution and age. For example, salamanders in lower animals have the complete regenerative capacity in limbs, while in most mammals including humans, limited regeneration and functional recovery capabilities reside in young tissues and decline with age. To date, the molecular mechanism underlying the declined regenerative capacity with evolution and age remains poorly understood. Unlik......
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Developmental Cell | De novo generation of macrophage from placenta-derived hemogenic endothelium [2021-06-30]
On June 30, 2021，Professors Feng Liu (from Institute of Zoology, Chinese Academy of Sciences), Jing-Dong J. Han (from Peaking university), Hongmei Wang (from Institute of Zoology, Chinese Academy of Sciences) and Berthold Gottgens (from University of Cambridge) collaborate on a paper entitled “De novo generation of macrophage from placenta-derived hemogenic endothelium” in Developmental Cell journal. This work identifies and experimentally validates that a CD44+ subpopulation of placental endothelial cells (ECs) exhibi......
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Tick tock in the brain: Scientists provide molecular insights into primate hippocampal aging [2021-05-31]
Deep inside our brain is a region called the hippocampus. It plays a crucial role in learning and memory, and its progressive deterioration with age is functionally linked to a variety of human neurodegenerative diseases. But what drives it down the path of aging?...
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Researchers reveal the roles of protein O-GlcNAcylation in modulating human placental trophoblast differentiation [2021-02-25]
O-linked β-N-acetylglucosamine (O-GlcNAc) is a reversible and ubiquitous post-translational modification in eukaryotic cells, which are extensively involved in a wide range of cellular processes. There has been evidence suggesting the involvement of O-GlcNAcylation in embryonic development or fetal health, whereas the underlying mechanisms remain illusive....
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Scientists develop a new gene therapy strategy for delaying aging [2021-01-07]
How many aging-promoting genes are there in the human genome? What are the molecular mechanisms by which these genes regulate aging? Can gene therapy alleviate individual aging? Recently, the researchers from the Chinese Academy of Sciences have shed new light on the regulation of aging....
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Researchers reveal a unique cellular strategy in placenta to compensate nutrient deprivation during pregnancy [2021-01-07]
During pregnancy, the health of the mother and the fetus is dominated by the appropriate allocation of nutrients between the two individuals. Maternal-fetal material exchange predominantly depends on the placenta, which plays critical roles in sensing fetal nutritional demand, modulating maternal supply, and adapting its nutrient transport capacity. Failures in the regulatory network of placental functions lead to serious clinical complications, such as preeclampsia, recurrent miscarriage, and fetal growth restriction (FG......
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Researchers Provide Novel Insights into Human Skin Aging [2020-11-25]
In human, the skin is one of the organs that exhibit early-onset aging-associated dysfunction. As a critical physical barrier, the skin is composed of a variety of cell types including fibroblasts and keratinocytes. Due to its high heterogeneity, it is difficult to accurately reveal the cell type-specific molecular mechanisms of human skin aging, which hinders our understanding of human skin aging and the development of interventions for human skin aging and related diseases....
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Researchers reveal that METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA [2020-10-10]
Recently, scientists from the Institute of Zoology and Beijing Institute of Genomics of the Chinese Academy of Sciences have collaborated jointly to unveil a novel mechanism of METTL3 as well as m6A in regulating human stem cell senescence. This study entitled “METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA” was published online in Nucleic Acids Research on October 9th, 2020. Using including Hutchinson-Gilford progeria syndrome (HGPS) and Werner syndrome (WS), researchers explored the ......
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Researchers Reveal a New Role of CLOCK in Promoting Stem Cell Rejuvenation and Cartilage Regeneration by Stabilizing Heterochromatin [2020-08-03]
Circadian clock is an evolutionarily conserved biological timing system that stabilizes tissue and cellular homeostasis by synchronizing mammalian physiology and behaviors with the external light-dark cycle. Accumulating evidence indicates an inextricable link between the circadian clock and the aging process. Adult stem cell exhaustion or senescence is one of the aging hallmarks and a crucial driving force for human degenerative disorders such as aging-related articular degeneration. However, the role of core circadian c......
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UTX Regulates Human Neural Differentiation and Dendritic Morphogenesis [2020-07-20]
Aberrant neural differentiation and dendritic morphogenesis in neurons are pervasive in many developmental brain disorders. The histone demethylases UTX regulates the dynamic steady-state levels of di-methylation and tri-methylation of histone H3 lysine 27 (H3K27), which is believed as a repressive epigenetic mark for maintaining transcriptional gene silencing. Deletion of Utx results in increased anxiety-like behaviors and impaired spatial learning and memory in mice. However, so little is known about the function of UTX......
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