Recent pubilications:                            more

Zhao C., Zhang Y., Zhao Y., Ying Y., Ai R., Zhang J., and Wang Y. (2018). Multiple Chemical Inducible Tal Effectors for Genome Editing and Transcription Activation. ACS Chem Biol 13, 609-617.


Wang L., Tu Z., Liu C., Liu H., Kaldis P., Chen Z., and Li W. (2018). Dual roles of TRF1 in tethering telomeres to the nuclear envelope and protecting them from fusion during meiosis. Cell Death Differ.


Qiao H., Li Y., Feng C., Duo S., Ji F., and Jiao J. (2018). Nap1l1 Controls Embryonic Neural Progenitor Cell Proliferation and Differentiation in the Developing Brain. Cell Rep 22, 2279-2293.


Shen T., Ji F., Wang Y., Lei X., Zhang D., and Jiao J. (2017). Brain-specific deletion of histone variant H2A.z results in cortical neurogenesis defects and neurodevelopmental disorder. Nucleic Acids Res.


 

Recent Progress:                                   more

Inhibition of PDE10A rescues impaired social behavior, learning and memory in mice with partial loss of MIR137 Autism spectrum disorder (ASD) is a group of neuropsychiatric disorders characterized by restricted interests, repetitive behaviors, and difficulty with social communication and interaction. The molecular mechanisms underlying the pathogenesis of ASD are poorly understood. Previous meta-analyses ......


Human Embryonic Stem Cells-derived Dopaminergic Neurons Alleviate Symptoms of Parkinson’s Disease in Monkeys Parkinson's disease (PD) is one of the leading neural degenerative disorders, which is primarily caused by death of dopaminergic neurons in substantia nigra. This type of disorder is now possibly treated using stem cell-based strategy, such as transplantation of human embryonic stem cells (hESCs)......


Yu Wang and Colleagues Review the Basic and Translational Studies of Hedgehog Signaling in Cell Chemical Biology Hedgehog (HH) signaling plays an important role in certain types of adult stem cells and cancer stem cells. Its aberrant activity is linked to degenerative diseases and a multitude of cancers. Considerable interest has focused on studying the mechanisms of HH signaling pathway and the identificat......


Chinese scientists discover an important regulator involved in alternative mRNA splicing in mouse spermatogonia and the transition to meiosis Alternative splicing significantly expands the form and function of the genome of organisms with limited gene number and is especially important for several stages of mouse spermatogenesis. In addition, a number of trans-acting regulators of pre-mRNA splicing are primarily or exclusively expresse......


Recent News                                     more

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Chinese researchers produce mouse pups with same-sex parents WASHINGTON, Oct. 11 -- Chinese researchers produced healthy mice with two mothers that went on to have normal offspring of their own. ...


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The first debate competition is preparing The state key laboratory of reproductive biology will hold the first session of debate competition. The title of the competition is “If sperm is more important than oocyte?” The leader of the district side is Wei Li and the a......


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