State Key Laboratory of Stem Cell and Reproductive Biology (SRLab)

Recent pubilications: more

Aging Atlas: a multi-omics database for aging biology. Nucleic Acids Res, 2021. 49: D825-d830.

Bi D^#, Yao J^#, Wang Y, Qin G, Zhang Y, Wang Y, Zhao J*. CRISPR/Cas13d-mediated efficient KDM5B mRNA knockdown in porcine somatic cells and parthenogenetic embryos. Reproduction, 2021. 162: 149-160.

Bian X^#, Liu J, Yang Q, Liu Y, Jia W, Zhang X, Li YX, Shao X*, Wang YL*. MicroRNA-210 regulates placental adaptation to maternal hypoxic stress during pregnancy. Biol Reprod, 2021. 104: 418-429.

Cao J^#, Hao J^#, Wang L^#, Tan Y, Tian Y, Li S, Ma A, Fu B, Dai J, Zhai P, Xiang P, Zhang Y, Cheng T*, Peng Y*, Zhou Q*, Zhao T*. Developing standards to support the clinical translation of stem cells. Stem Cells Transl Med, 2021. 10 Suppl 2: S85-s95.

Chen L^#, Gao H^#, Zhou B*, Wang Y*. Comprehensive optimization of a reporter assay toolbox for three distinct CRISPR-Cas systems. FEBS Open Bio, 2021a. 11: 1965-1980.

Recent Progress: more

Chinese Scientists Uncover Metformin′s Potential to Delay Aging in Primates A pivotal discovery in aging research by a Chinese Academy of Sciences (CAS) team has shown that metformin, commonly used for type 2 diabetes, can alleviate cellular senescence, markedly slowing down the aging process in primates. This breakthrough offers fresh insights into aging biology and hol......

Deciphering the Pathological Mechanisms of Spermatogenic Impairment in Cryptorchidism Cryptorchidism is a common congenital abnormality in male newborns. Studies have found that cryptorchidism is associated with a high prevalence of male infertility, with nearly 10% of men with fertility problems having a history of cryptorchidism. However, the pathogenesis of cryptorchidism that ......

Role of Metabolites in Human Placental Health Unveiled A study, led by Prof Ng Shyh-Chang, Prof Wang Yan-Ling and Prof Wang Hongmei from the Beijing Institute of Stem Cells and Regenerative Medicine and CAS Institute of Zoology, delved into the intricate workings of placental trophoblast stem cells. Researchers discovered that these cells require a p......

Novel Gene Writing Technology Enables All-RNA-mediated Targeted Gene Integration in Human Cells In a recent study published in Cell, a research team led by LI Wei and ZHOU Qi from the Institute of Zoology of the Chinese Academy of Sciences has developed an innovative gene-writing technology based on retrotransposons. This achievement enables all-RNA-mediated targeted gene integration in hum......

Recent News more

Chinese researchers produce mouse pups with same-sex parents WASHINGTON, Oct. 11 -- Chinese researchers produced healthy mice with two mothers that went on to have normal offspring of their own. ...

The first debate competition is preparing The state key laboratory of reproductive biology will hold the first session of debate competition. The title of the competition is “If sperm is more important than oocyte?” The leader of the district side is Wei Li and the a......

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