Life begins with the fusion of oocyte and sperm. By using the materials from mouse, non-human primate and clinic treatment, my group focus on the mechanisms of oogenesis, meiotic maturation and fertilization.

Maternal factors regulate the establishment of H3K27 methylation in zygote

Post-translational modification of Bin2 mediates female fertility

Plain English:
Current interests in my laboratory include: (i) reveal the mechanisms of oogenesis and meiotic maturation. (ii) dissection of the basis of fertilization and life initiation.

Selected publications:

1. Zhu FY*, Wang LL*, Meng TG*, Wang RL*, Yang ZX*, Cao Y, Zhu GY, Jin Z, Gao LL, Zeng WT, Wang ZB#, Sun QY#, Zhang D#(2021). Inhibiting bridge integrator 2 phosphorylation leads to improved oocyte quality, ovarian health and fertility in aging and after chemotherapy in mice. Nat Aging （in press）
2. Meng TG*, Zhou Q*, Ma XS*, Liu XY*, Meng QR, Huang XJ, Liu HL, Lei WL, Zhao ZH, Ouyang YC, Hou Y, Schatten H, Ou XH#, Wang ZB#, Gao SR#, Sun QY#（2020）. PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome. Nat Commun. Dec 11;11(1):6354.
3. Meng TG*, Lu X*, Guo L*, Hou GM, Ma XS, Li QN, Huang L, Fan LH, Zhao ZH, Ou XH, OuYang YC, Schatten H, Li L, Wang ZB#, Sun QY# (2019). Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation. FASEB J . Jan;33(1):1179-1187.
4. Hu MW*, Meng TG*, Jiang ZZ, Dong MZ, Schatten H, Xu X, Wang ZB#, Sun QY# (2016). Protein Phosphatase 6 Protects Prophase I-Arrested Oocytes by Safeguarding Genomic Integrity. PLoS Genet . Dec 8;12(12):e1006513.
5. Wang ZB*, Jiang ZZ, Zhang QH, Hu MW, Huang L, Ou XH, Guo L, Ouyang YC, Hou Y, Brakebusch C, Schatten H, Sun QY# (2013).Specific deletion of Cdc42 does not affect meiotic spindle organization/migration and homologous chromosome segregation, but disrupts polarity establishment and cytokinesis in mouse oocyte. Mol Biol Cell  24(24):3832-41.
6. Wang ZB*, Schatten H, Sun QY# (2011).Why is Chromosome Segregation Error in Oocytes Increased With Maternal Aging. Physiology  (Bethesda) 26(5):314-25.