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Jianwei JIAO, Ph. D.

Neural Stem Cell and Neurogenesis


Co-workers: Fen Ji, Xiaohui Lv, Hong Li, Juan Zhang, Zixiao Shi, Shukun Wang, Xuepei Lei, Qingli Liang, Tianjin Shen, Wenlong Xia, Baoguo Li

• JIAO Group website

 

  Our laboratory studies what mechanisms control stem cells to become neurons for repairing neurodegenerative diseases and how to generate induced neuronal (iN) cells. There are several ongoing projects in our lab.

  1. Studying the mechanisms involving neural stem cell proliferation and neurogenesis During mammalian embryonic brain development, the generation of three major neural cell types (neuron, astrocyte and oliogodentryocyte) from neural stem cell follows an evolutionarily conserved temporal and spatial sequence. Neurogenesis precedes gliogenesis throughout the central nervous system (CNS). Both cell intrinsic factors and extracellular cues have been postulated to influence the neurogenic to gliogenic switch. We will use several strategies to identify what signaling molecules that control this process. We are also interested in studying what mechanisms control adult neural stem cell proliferation and neurogenesis.

  2. Generating induced neuronal cells The direct conversion of somatic mouse fibroblasts to induced neuronal cells has been reported by transfection of neuronal specific transcription factors. We aim to generate iN cells from fibroblasts using non-integration adenovirus system and find whether other transcription factors can be used to convert fibroblasts to neurons with high efficiency.



Studying trans-differentiation from fibroblasts to neurons



Studying epigenetic molecules in neural stem cell and neurogenesis

 

Plain English:
  Our laboratory focuses on studying what mechanisms and signaling pathways control stem cell proliferation and neurogenesis. Identification of neuron-specific genes or miRNAs from neural stem cells is the direction of this study. There are several research directions including what mechanisms involving neural stem cell proliferation and neurogenesis and how to convert fibroblasts to neurons.

 

Selected publications:

  1. Li Y, Jiao J*. Histone chaperone HIRA regulates neural progenitor cell proliferation and neurogenesis via β-catenin. J Cell Biol, 2017 (accepted).
  2. Xia W, Jiao J*. Histone variant H3.3 orchestrates neural stem cell differentiation in the developing brain. Cell Death Differ, 2017 (accepted).
  3. Ji F, Shen T, Zou W, Jiao J*. UCP2 Regulates Embryonic Neurogenesis via ROS-Mediated Yap Alternation in the Developing Neocortex. Stem Cells, 2017 Mar 9. doi: 10.1002/stem.2605.
  4. Zhang J, Chen S, Zhang D, Shi Z, Li H, Zhao T, Hu B, Zhou Q, Jiao J*. Tet3-Mediated DNA Demethylation Contributes to the Direct Conversion of Fibroblast to Functional Neuron. Cell Rep, 2016 17:2326–2339.
  5. Wang S, Liang Q, Qiao H, Li H, Shen T, Ji F, Jiao J*. DISC1 regulates astrogenesis in the embryonic brain via modulation of RAS/MEK/ERK signaling through RASSF7. Development, 2016 143:2732-2740.
  6. Jiang H, Lv X, Lei X, Yang Y, Yang X, Jiao J*. Immune Regulator MCPIP1 Modulates TET Expression During Early Neocortical Development. Stem Cell Reports, 2016 7:439-453.
  7. Shi Z, Zhang J, Chen S, Li Y, Lei X, Qiao H, Zhu Q, Hu B, Zhou Q, Jiao J*. Conversion of Fibroblasts to Parvalbumin Neurons by One Transcription Factor, Ascl1, and the Chemical Compound Forskolin. J Biol Chem, 2016 291:13560-13570.
  8. Shen T, Ji F, Yuan Z, Jiao J*. CHD2 is required for embryonic neurogenesis in the developing cerebral cortex. Stem Cells 2015 33:1794-1806.
  9. Xia W, Liu Y, Jiao J*. GRM7 regulates embryonic neurogenesis via CREB and YAP. Stem Cell Reports 2015 4:795-810.
  10. Lv X, Jiang H, Liu Y, Lei X, Jiao J*. MicroRNA-15b promotes neurogenesis and inhibits neural progenitor proliferation by directly repressing TET3 during early neocortical development. EMBO Rep 2014 15:1305-1314.
  11. Wang S, Li B, Qiao H, Lv X, Liang Q, Shi Z, Xia W, Ji F, Jiao J*. Autophagy-related gene Atg5 is essential for astrocyte differentiation in the developing mouse cortex. EMBO Rep 2014 15:1053–1061.
  12. Zhang J, Ji F, Liu Y, Lei X, Li H, Ji G, Yuan Z, Jiao J*. Ezh2 regulates adult hippocampal neurogenesis and memory. J Neurosci 2014 34:5184-5199.
  13. Huang W, She L, Chang X, Yang R, Wang L, Ji H, Jiao J, Poo M. Protein kinase LKB1 regulates polarized dendriteformation of adult hippocampal newborn neurons. Proc Natl Acad Sci USA 2014 111:469-474.
  14. Yao M, Wang Y, Zhang P, Cheng H, Xu Z, Jiao J, Yuan Z. BMP2-SMAD signaling represses the proliferation of embryonic neural stem cells through YAP. J Neurosci 2014 34:12039 –12048.
  15. Shi Z, Shen T, Liu Y, Huang Y, Jiao J*. Retinoic acid receptor gamma (Rarg) and nuclear receptor subfamily 5, group A, member 2 (Nr5a2) promote conversion of fibroblasts to functional neurons. J Biol Chem 2014 289:6415-6428.
  16. Meng F, Chen S, Miao Q, Zhou K, Lao Q, Zhang X, Guo W, Jiao J*. Induction of fibroblasts to neurons through adenoviral gene delivery. Cell Res 2012 22:436-440.
  17. Jiao J, Feldheim DA, Chen DF. Ephrins as negative regulators of adult neurogenesis in diverse regions of the central nervous system. Proc Natl Acad Sci USA 2008 105: 8778-8783.
  18. Jiao J, Chen DF. Induction of neurogenesis in non-conventional neurogenic regions of the adult CNS by niche astrocyte-produced signals, Stem Cells 2008 26:1221-1230.
  19. Jiao J, Huang X, Feit-Leithman RA, Neve RL, Snider W, Dartt DA, Chen DF. Bcl-2 enhances Ca2+ signaling to support the intrinsic regenerative capacity of CNS axons. EMBO J 2005 24:1068-1078.