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Chang-Mei LIU, Ph. D.

Stem cell and Neurological Diseases.


Staff: Gangbin Tang, HongZhen Du
Postdoc: Guang-Jian Qi, Ning Du
Students: Pei-Pei Liu, Ya-Jie Xu, Shuang-Feng Zhang, Ping Li, Run-Shan Duan, Shang-Kun Dai, Qing-Yuan Tang

• LIU Group website


 

  Brain is the organ that coordinates and controls body activities and functions, and serves as the center of memory, thought, and feeling. Neurogenesis, a process of generating functional neurons from neural stem cells and progenitor cells, is important for neuroplasticity and intricate neural network in the nervous system. The intricate neural network formation during embryonic and perinatal development is fundamental for proper brain functions. Aberrant neural network formation has been suggested to be the cellular basis for many mental disorders. We are interested in understanding the molecular and cellular mechanisms for stem cell maintenance and stem cell differentiation during early neural development and in adulthood. We are also interested in elucidating the roles of epigenetic genes in neurological diseases and mental disorders with neural developmental origins, such as autism. Finally, we would like to develop novel stem cell-based strategies to treat neurological diseases and mental disorders.

 

 

Selected publications:

  1. Jiang JJ*, Liu CM*, Zhang BY, Wang XW, Zhang M, Saijilafu, Zhang SR, Hall P, Hu YW, Zhou FQ. MicroRNA-26a supports mammalian axon regeneration in vivo by suppressing GSK3β expression. Cell Death and Disease (2015) 6, e1865 (*Co-first author).
  2. Liu CM*, Wang RY*, Saijilafu, Jiao ZX, Zhang BY, Zhou FQ. MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration. Genes Dev. 2013, 27(13):1473-83(*Co-first author).
  3. Liu CM*, Teng ZQ*, Santistevan NJ, Szulwach KE, Guo W, Jin P, Zhao X. Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation. Cell Stem Cell. 2010, 6(5):433-44 (*Co-first author).
  4. Saijilafu, Hur EM, Liu CM, Jiao ZX, Xu WL, and Zhou F-Q. PI3K-GSK3 pathway regulates mammalian axon regeneration by induction of Smad1. Nature Communications, 2013, 4:2690.
  5. Guo W, Zhang Li, Christopher DM, Teng ZQ, Fausett SR, Liu CM,  George OL, Klingensmith J, Jin P, Zhao X. 2011. RNA binding protein FXR2 regulates proliferation and differentiation of adult hippocampal neural stem cells by repressing Noggin expression. Neuron, 70:924-938.
  6. Liu CM, Teng ZQ, McQuate AL,  Jobe EM,  Christ CC, Hoyningen-Huene SJ, Reyes MD, Polich ED, Xing Y, Li Y, Guo W, Zhao X. An Epigenetic Feedback Regulatory Loop Involving MicroRNA-195 and MBD1 Governs Neural Stem Cell Differentiation PLoS One. 2013; 8(1): e51436.
  7. Li X, Barkho BZ, Luo Y, Smrt RD, Santistevan NJ, Liu C, Kuwabara T, Gage FH, Zhao X. Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. J Biol Chem. 2008 Oct 10;283 (41):27644-52.
  8. Luo Y, Shan G, Guo W, Smrt RD, Johnson EB, Li X, Pfeiffer RL, Szulwach KE, Duan R, Barkho BZ, Li W, Liu C, Jin P, Zhao X. Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. PLoS Genet. 2010 Apr 8;6(4): e1000898.
  9. Liu CM, Zhao XY. MicroRNAs in adult and embryonic neurogenesis. Neuromolecular Med. 2009;11 (3):141-52.
  10. Liu CM, Yang Z, Liu CW, Wang R, Tien P, Dale R, Sun LQ. Myostatin antisense RNA-mediated muscle growth in normal and cancer cachexia mice. Gene Ther. 2008 Feb; 15 (3):155-60.
  11. Liu CM, Yang Z, Liu CW, Wang R, Tien P, Dale R, Sun LQ. Effect of RNA oligonucleotide targeting Foxo-1 on muscle growth in normal and cancer cachexia mice. Cancer Gene Ther. 2007 Dec;14 (12):945-52.
  12. Gong H, Liu CM, Liu DP, Liang CC. The role of small RNAs in human diseases: potential troublemaker and therapeutic tools. Med Res Rev. 2005 May;25(3):361-81.
  13. Ke XS, Liu CM, Liu DP, Liang CC. MicroRNAs: key participants in gene regulatory networks. Curr Opin Chem Biol. 2003 Aug; 7(4):516-23.