Home > Groups > Hongmei WANG




Hongmei Wang


Professor of State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology (IOZ)

Chinese Academy of Sciences (CAS)


Assistant director of IOZ

Director of State Key Laboratory of Stem Cell and Reproductive Biology, IOZ, CAS

Director of Institute of Reproductive Health, Institute for Stem cell and Regeneration, CAS


1, Beichen West Rd, Chaoyang District

Beijing 100101, P.R. China

Telephone: 086-10-64807187

Fax: 86-10-64807316

Email: wanghm@ioz.ac.cn


Group website: http://www.rpb.ioz.ac.cn/yjz/wanghongmei/201401/t20140128_157927.html



Department of Biology, Beijing Normal University

M. M. in Biology


Institute of Cell Biology, College of Life Sciences, Beijing Normal University

M. B. in Cell Proliferation and Regulation Biology

Supervised by Yongchao Wang, Professor


State Key Lab of Reproductive Biology, Institute of Zoology, CAS

Ph.D. in Reproductive Physiology

Supervised by Cheng Zhu, Professor



Professor of State Key Laboratory of Stem Cell and Reproductive Biology

Institute of Zoology, CAS


Associate Professor of State Key Laboratory of Stem Cell and Reproductive Biology

Institute of Zoology, CAS


Post-doctoral fellow

Ottawa Health Research Institute, University of Ottawa

Supervised by Dr. Benjamin K Tsang


Assistant Professor of State Key Laboratory of Stem Cell and Reproductive Biology

Institute of Zoology, CAS


Research Associate of State Key Laboratory of Reproductive Biology

Institute of Zoology, CAS



Ferring project: Circulating fetal trophoblast cells (CFTCs) and their prospects to monitor the outcomes and pregnancy process. (Ferring Phamaceuticals) (427, 850 U.S dollar RMB2,860,000)


Ferring project:Identification of placenta-specifically expressed proteins or peptides. (Ferring Phamaceuticals) (448, 800 U.S dollar RMB3,000,000)


Strategic International Cooperation in Science and Technology Innovation Key Program: The metabolic regulation of placenta formation. (MOST) (231, 283 U.S. dollar RMB1, 620, 000)


The National Key Research and Development Program: The mechanism of lineage differentiation of trophoblast cells in human placenta. (MOST) (128,490 U.S. dollar RMB900, 000)


Strategic Priority Research Program of CAS: Reconstruction of genital organs and in vitro generation of life. (1,421,000U.S. dollar RMB10,000,000)


The National Key Research and Development Program: Stem cell-based maintenance and reconstruction of fertility. (MOST) (853,000U.S. dollar RMB6,000,000)


The National Key Research and Development Program: The influence and mechanism of pregnancy-associated factors on offspring health. (MOST) (370,000U.S. dollar RMB2,601,300)


The National Key Research and Development Program: The regulatory mechanism of formation and differentiation of peri-implantation blastocysts. (MOST) (24,000U.S. dollar RMB170,000)


Key Program of National Natural Science Foundation of China (NSFC): Pathogenesis of recurrent spontaneous abortion and preeclampsia in association with abnormal placenta development. (163,000U.S. dollar RMB1,150,000)


National Science Fund for Distinguished Young Scholars of China, NSFC: Pregnancy and pregnancy-related diseases. (40,000 U.S. dollar RMB 2,800,000)


A General Project of NSFC: The role of Furin in trophoblast syncytialization and the underlying molecular mechanism. (88,000U.S. dollar RMB 620,000)


CAS Pilot Project: Cellular aspects of somatic cell reprogramming. (CAS) (327,000U.S. dollar RMB 2,300,000)


National Key Basic Research Program "973" Project: Molecular basis of pregnancy establishment and maintenance. (MOST) (284,000U.S. dollar RMB 2, 000, 000)


National Key Technology Research and Development Program of Ministry of Science and Technology of the People’s Republic of China (MOST): Establishment of the animal models for major diseases and its evaluation system. (284,000U.S. dollar RMB 2,000,000)


Main Direction Program of Knowledge Innovation of CAS: Molecular markers, diagnosis and treatment of pregnancy-related diseases. (CAS)(119,000U.S. dollar RMB 840,000)


A General Project of NSFC: CUL7 E3 ligase in trophoblast invasion and migration. (46,000U.S. dollar RMB 320,000)


China-Canada Joint Health Research Project (NSFC-CIHR (Canada Institute of Health Research) International Cooperation Project): The role of proteolytic processing of IGFBP-3 in embryonic implantation. (64,000U.S. dollar RMB 450,000)


A General Fund from Ministry of Education (MOE): Function of Proprotein Convertases (PCs) in embryo implantation. (43,000U.S. dollar RMB 300, 000)


Main Direction Program of Knowledge Innovation of CAS: Using the rat-mouse sterility model to study the molecular mechanism of embryonic implantation. ((47,000U.S. dollar RMB 330,000)


A General Project of NSFC: The functional mechanism of Proprotein Convertases (PCs) in embryonic implantation: Study on RNAi and Proteomics. (40,000U.S. dollar RMB 280,000)


National Program on Key Basic Research Project of China, MOST: Regulatory mechanism of trophoblast cell differentiation. (568,000U.S. dollar RMB 4,000,000)


National Program on Key Basic Research Project of China (973 Program), MOST: Molecular basis of controlled trophoblast cell invasion. (212,000U.S. dollar RMB 1,490,000)


A Special Foundation from the President of CAS: Involvement of TGF beta signaling in restrictive invasion of trophoblast cells. (36,000U.S. dollar RMB250, 000)


National Science Foundation for Young Scientists of China: Research on the regulation of implantation-related factors by RNAi.(NSFC) (36,000U.S. dollar RMB250, 000)


For many years, my lab has been working on key factors/pathways involved in embryonic development and placental trophoblast differentiation, and has gained valuable information of the important functions of the ubiquitin-proteasome pathway, TGF-β signaling pathway, proprotein convertases and corticosteroid binding globulin (CBG) in embryo implantation, placentation and pregnancy maintenance by combining a well-established platform for placenta and embryo research (including various trophoblast cell fusion/invasion/migration models, trophoblast stem cells, live-cell imaging, tissue clearing, in vivo lineage tracing, placenta-specific knockout or knockdown mouse models, in vitro long-term culture system for mice and monkey embryos, live-cell imaging, tissue clearing, in vivo lineage tracing, placenta-specific knockout or knockdown mouse models, high-throughput proteomics, single cell RNA-seq, and cutting-edge molecular and biochemical technologies) and a clinical sample library on pregnancy-related diseases.

We are aimed at investigating the molecular mechanisms involved in placental development, particularly in the area of trophoblast differentiation including invasion and syncytialization of the trophoblast lineage and placentation-related diseases, such as fetal growth restriction (FGR) and preeclampsia. Human placental villous trophoblast cells undergo terminal differentiation and fusion to form the multinucleated syncytiotrophoblast, while the extravillous cytotrophoblast infiltrates the endomyometrium to anchor the placenta. Inadequate/excessive invasion of trophoblast or dysregulation in syncytialization results in early pregnancy loss, FGR or preeclampsia, etc. The main research interest of us is to study the physiological mechanisms of placentation and related complications and diseases, especially the key events including trophoblast invasion /migration and syncytialization, the crosstalk between trophoblast and decidual immune cells.

we also focus on investigating the pathological dysfunction and physiological aging of the ovary. The pathogenesis and treatment of ovarian dysfunction, especially premature ovarian insufficiency, are of interest to us. We are also studying the mechanisms that regulate normal ovarian physiological aging to find the secret of senility. In addition, building a complete data model of follicle number with age is an important challenge in understanding ovarian reproductive aging. The aims of these works are to understand the ovarian physiology and to promote the theoretical development and clinical transformation of the treatment of ovarian diseases and fertility recovery in women.

Primate’s embryogenesis at early stages is another subject we are focusing on, especially at the post-implantation stage, ranging from the angiogenesis, embryonic disc formation and early placentation, gastrulation, neurulation and organogenesis. To reveal the most essential but special developmental stage, we set up mouse, monkey and human blastocyst long-term in vitro culture system, which could support mouse and monkey embryos in vitro developing beyond early gastrulation, and support human embryos to embryonic day 14 (ethical limitation).


1) The construction of human and mouse placenta atlas

To understand the placenta better, we need to systematically know how the placenta is developed, that is, how different trophoblast lineages are specified. Human placenta is a very complicated organ. The cell types and the function of the placenta varies with the progression of pregnancy. We isolated human placental cells at different stages of pregnancy, under physiological or pathological (preeclampsia, placenta accrete, etc.) conditions and subjected them to the single cell RNA-seq analysis (10X genomics and Smart seq2) to classify different types placental cells, in order to find as many types of placental cells as possible. Then based on the transcriptome of each type of cells, we hope to find the specific markers for each population of cells and isolate these cells and further study their functions. On the other hand, we will study how the trophoblast lineages are specified. With this, we hope to eventually generate the human placenta atlas. We will use similar strategy to try to specify mouse trophoblast lineages.

2) The recapitulation of primate gastrulation in vitro

Gastrulation is a developmental process which occurred represented by the differentiation, migration and rearrangement of gastrulating cells, and eventually leads to the formation of three germ layers and the establishment of anterior-posterior(A-P)axis. Therefore, the orderly occurrence of gastrulation sets an important foundation for the body plan and organogenesis. Due to the inaccessibility of post-implantation embryos and the limitation of detective techniques and research ethics, the gastrulation of primate embryos still maintains mysterious. To uncover the mysterious mask of gastrulation, we established an in vitro culture (IVC) system that supports the continuous development of cynomolgus monkey blastocysts beyond early gastrulation and to 20 days post fertilization. The IVC embryos highly recapitulated the key events of in vivo early post-implantation development without the maternal support, which were proved by morphologies detection, specific markers identification and scRNA-seq analysis. This study will provide an important theoretical basis for primate embryonic gastrulation and human early embryonic development and related diseases. We will further optimize the long-term IVC system, and promote mammal (non-human primate and rodent) embryos to more advanced developmental stages.

3) The mechanism and function of human trophoblast primary/secondary syncytialization

Implantation of the blastocyst is a developmental milestone in mammalian embryonic development. During embryo implantation, a trophectoderm-derived multinucleated syncytiotrophoblast connects the fetus and the mother. The formation of this primary syncytiotrophoblast determines the successful implantation. However, this process remains mysterious in despite of its basic and clinical importance. According to the textbook, the primary syncytiotrophoblast is formed by cell fusion. However, the existence of the obvious big nuclei in the syncytiotrophoblast suggests atypical cell fusion or endoreduplication. We are taking advantage of a novel in vitro culture system to cultivate human embryos and studying how the primary syncytiotrophoblast is formed. At the same time, we are also interested in studying the function of the primary syncytiotrophoblast and comparing the difference between primary and secondary syncytialization using trophoblast stem cell differentiation model and primary cultures. Using a similar culture system, monkey embryos are cultured in vitro beyond early gastrulation. We are using the in vitro monkey embryo model (with Zhou Qi lab and Li Lei Lab) to study trophoblast differentiation at early stages of gestation.

4) 3D imaging of mouse placenta using a modified tissue clearing method

Understanding the placental vasculature (maternal and fetal blood vessels) is crucial to elucidate the normal and pathological placental functions. The previous evidence on placental vasculature is mostly based on classical tissue sections and histological techniques and they are at 2D level. Analyzing the placental blood vessels at 3D level will provide more accurate global structural changes in the placenta. Work in James C. Cross’s lab provided the first comprehensive description of the anatomy vascular space in the mouse mature placenta by plastic vascular casts. However, owing to the small diameter of the vessels and the plastic viscosity, the fetal side casts were impossible for the placentas before E12.5. The architecture of placental vasculature in the early development is thus missing. We are taking advantage of a modified tissue clearing system combining PACT and CUBIC methods to study the anatomy of the mouse placenta at earlier pregnancy stage with light-sheet fluorescence microscopy, in order to obtain the long missing architecture of the fetal placenta vascular network after chorioallantoic attachment. At the same time, we also cleared the mouse uterus and oviduct (with Duan Lab) to study how the mouse uterine glands are developed and how the sperms cooperate to enter into female oviduct.

5) MSCs transplantation to treat women with pathological or physiological ovarian failures

Pathological ovarian failure (premature ovarian insufficiency [POI]) and physiological ovarian failure (menopausal syndrome) affect not only women’s fertility, but also life quality. In recent years, MSCs have been successfully used to repair the damaged ovarian function in mice, rats, rabbits, etc. We also showed that human umbilical cord MSCs restored ovarian function in mice (chemotherapy-induced POI mouse model and aged mouse model). With an aim to test the clinical efficacy of MSCs in alleviating pathological and physiological ovarian senescence, we have recruited patients with POI and menopausal syndrome, injected MSCs into the patients’ ovaries, and examined sex hormone levels (AMH, FSH and E2), ovary volume, antral follicle number, pregnancy rate to assess the curative effect.




“Ten Million Talents Program” as middle-aged expert with outstanding contributions


Distinguished Young Scholars of China, National Natural Science Foundation of China


First Prize in Outstanding Scientific Achievement Award, National Population and Family Planning Commission, P. R. China


Second Prize in Natural Science (the Ministry of Education)


A scholarship from Strategic Training Initiative Research in Reproductive Health Sciences, CIHR, Canada


Liu Yongling Award, CAS, China


Best Poster Award, 2nd Prize and 3rd Prize. Symposium on Tissue Remodeling: Growth, Apoptosis, and Differentiation, Tainan, Taiwan



Advisory Board Member, Cell Reports Medicine


Chairman, Chinese Society of Reproductive Biology


Editor, Cell Proliferation


Editor, Biology of Reproduction


Membership Committee Member, Society for the Study of Reproduction, USA


2017 Program Committee Member, Society for the Study of Reproduction, USA


International Members, Subcommittee member, Society for the Study of Reproduction, USA


Management Committee, Chinese Society of Reproductive Biology


Member, Society for the Study of Reproduction, USA



Invited speaker; Science Asia Conference on Advanced Technologies in Biomedicine, Beijing, China; “Deciphering the secrets of how primates are formed”.


Invited speaker; Cold Spring Harbor Asia conference on Frontiers in Single Cell Genomics, Suzhou, China; “Cell fate determination in the human placenta”.


Plenary speaker; 2018 Mammalian Reproduction Gordon Research Conference, Lucca, Italy; “Syncytiotrophoblast of the Human Placenta and the Pregnancy Outcome”.


Invited speaker; 2017 ASCB, EMBO Meeting, Philadelphia, USA; Subgroup P: Cell-Cell Fusion; “Human placental syncytialization: from the very first fusion event to the largest syncytia”.


Plenary speaker; The 4th SKLRB Symposium on Reproductive Biology, Beijing, China; “Molecular mechanism guiding human trophoblast differentiation”.


Co-Chair; Third SKLRB Symposium on Frontiers in Reproductive Biology, Beijing, China.


Plenary speaker and Co-Chair; International Conference on Women’s Reproduction Health, Ottawa, Canada; “Differentiation of human trophoblast cells and complications of human pregnancy”.


Plenary speaker; 2013 ISPR Annual Meeting, Tel Aviv, Israel; “Human trophoblast differentiation and regulation”.


Plenary speaker; EMBO Workshop on Cell-cell Fusion, Ein Gedi, Israel; “Trophoblast fusion: from key molecules to live-cell imaging”.


Plenary speaker; The 2nd SKLRB Symposia on Frontiers in Periimplantation Biology, Beijing, China; “Revealing the hidden puzzles of human trophoblast syncytialization”


Plenary speaker; Biomodulation Symposium: Biotechnology for Future Era, Seoul, Korea; “Proprotein convertases Furin is required for syncytialization of trophoblast cells”


Plenary speaker; The 2nd International Conference on Reproductive Immunology, Shanghai, China; “Syncytialization of human trophoblast cells”


Plenary speaker; The First SKLRB Symposia on Frontiers in Periimplantation Biology, Beijing, China; “Ubiquitin ligase Cullin 7 induces epithelial-mesenchymal transition in human choriocarcinoma cells”.


Plenary speaker; The Second Sino-Canada Bilateral Workshop on Reproductive Health Research, Ottawa, Canada; “Study on the menstruation and early pregnancy of fulvous fruit bats”.


Invited speaker; Short talk; SSR's 38th Annual Meeting, Quebec, Canada; “Regulation of Rat Granulosa cell apoptosis by Nodal/AKL7-signaling pathway”.


Assistant Professor

Long Yan, Ph. D


Lab manager

Yucui Shen


Postdoctoral Fellow

Xiangxiang Jiang

Yawei Liu

Zhenyu Xiao

Jiawei lv

Jinglei Zhai


Ph. D.

Yiming Wang

Gang Chen

Dainan Yu

Xulun Wu

Yue Wang

Yan Zhao

Hao Wu

MSc student

Shuo Chen

Yin Rong

Run Sun

Feiyan Zhao

Wan Tu



Past Appointment

Last Known Affiliation

Wenxiang Luo

Ph.D. Student (1997)

University of Wisconsin, Madison

Yunge Zhao

Ph.D. Student (1999)

University of Virginia

Longjiang Shao

Ph.D. Student (2001)

Baylor College of Medicine

Qinglei Li

Postdoctoral Researcher (2002)

Texas A&M University

Donglin Liu

Ph.D. Student (2003)

University of Medicine/Dentistry of New Jersey

Xuan Zhang

Ph.D. Student (2003)

Shanghai Institute of Planned parenthood Research

Dong Qian

Ph.D. Student (2004)

Emory University

Haiyan Lin

Ph.D. Student (2005)

The university of British Columbia

Hongxing Wang

Ph.D. Student (2005)

Harvard Medical School

Heng Zhang

Ph.D. Student (2006)

University of Northwestern

Qing Yang

Ph.D. Student (2006)

Hunan Agricultural University

Xiaoping Zhang

Ph.D. Student (2007)

Ohio State University

Jiejun Fu

Ph.D. Student (2008)

Guangxi Medical University

Baohua Zhang

Ph.D. Student (2009)

University of Ottawa

Chuang Li

Ph.D. Student (2010)

Washington University in St. Louis

Zhi Zhou

Ph.D. Student (2011)

Shanghai technology University

Liang Wu

Ph.D. Student (2011)

The First Affiliated Hospital of Zhengzhou University

Kunqing Zhao

Ph.D. Student (2012)

Q2 Solutions Beijing

Rui Wang

Ph.D. Student (2015)

The University of Texas MD Anderson Cancer Center

Dandan Liu

Ph.D. Student (2015)

Peking University Third Hospital

Sumei Liu

Master’s Student (2014)

Xuanwu Hospital Capital Medical University

Ru Zheng

Ph.D. Student (2017)

Annoroad Gene Technology

Lina Cui

Ph.D. Student (2016)

Annoroad Gene Technology

Xing Huang

Ph.D. Student (2016)

Hamamatsu Photonics China

Qiang Fan

Ph.D. Student (2017)

Tsinghua University

Jiao Ma

Ph.D. Student (2020)

Peking University Third Hospital

Shanshan Guo

Ph.D. Student (2020)

Henan University of Technology

Ruoxuan Yu

Ph.D. Student (2020)

Abcam China

Peiye Yi

Master’s Student (2018)

Annoroad Gene Technology

Hang Cui

Master’s Student (2019)

China General Technology

Ping Lin

Visiting Student (2008)

Harbin Medical University

Ying Zhou

Visiting Student (2010)

Beijing Zhongguancun Hospital

Qingxin Wang

Visiting Student (2011)

Beijing Obstetrics and Gynecology Hospital, Capital Medical University

Qian Zhang

Visiting Student (2012)

Chongqing Medical University

Weiwei Li

Visiting Student (2014)

Beijing Normal University

Yue Li

Visiting Student (2015)

Harbin Medical University

Mingyue Nie

Visiting Student (2015)

Beijing Obstetrics and Gynecology Hospital, Capital Medical University

Min Li

Visiting Student (2016)

Chinese PLA General Hospital

Yuxia He

Visiting Student (2016)

Southern Medical University

Ying Fang

Visiting Student (2016)

Beijing Obstetrics and Gynecology Hospital, Capital Medical University

Meng Yang

Visiting Student (2017)

Anhui University

Liming Hong

Visiting Student (2019)

Beijing Obstetrics and Gynecology Hospital, Capital Medical University

PUBLICATIONS (#, equal contribution; *, corresponding authors)

  1. Zhao Y#, Ma J#, Yi P#, Wu J#, Zhao F, Tu W, Liu W, Li T, Deng Y, Hao J*, Wang H*, Yan L*. Human umbilical cord mesenchymal stem cells restore the ovarian metabolome and rescue premature ovarian insufficiency in mice. Stem Cell Research & Therapy. 2020 Nov 4,11(1),466. IF2019:5.116
  2. Yan L#, Wu Y#, Li L#, Wu J#, Zhao F, Gao Z, Liu W, Li T, Fan Y*, Hao J*, Liu J*, Wang H*. Clinical analysis of human umbilical cord mesenchymal stem cell allotransplantation in patients with premature ovarian insufficiency. Cell Proliferat. 2020, 53(12), e12938. IF2019:5.753
  3. Xiao Z#, Yan L#, Liang X*, Wang H*. Progress in deciphering trophoblast cell differentiation during human placentation. Current Opinion in Cell Biology. 2020, 18(67), 86-91. IF2019:8.240. (invited review)
  4. Lim H, Alvarez Y, Gasnier M, Wang Y, Tetlak P, Bissiere S, Wang H, Biro M, Plachta N*. Keratins are asymmetrically inherited cell fate determinants in the mammalian embryo. Nature, 2020, 585(7825):404-409.
  5. Xiao Z#, Yan L#, Liang X*, Wang H*. Progress in deciphering trophoblast cell differentiation during human placentation. Curr Opin Cell Biol, 2020, 18;67:86-91.
  6. Cui D#, Liu Y#, Jiang X#, Ding C, Poon L*, Wang H* , Yang H*. Single-cell RNA Expression Profiling of ACE2 and TMPRSS2 in the Human Trophectoderm and Placenta. Ultrasound Obstet Gynecol, 2020, Accepted.
  7. Jiang X, Wang H*. Macrophage subsets at the maternal-fetal interface. Cell Mol Immunol, 2020, 17(8):889-891.
  8. Gao H#, Liu C#, Wu B#, Wu B#, Cui H, Zhao Y, Duan Y, Gao F*, Gu Q*, Wang H*, Li W*. Effects of Different Biomaterials and Cellular Status on Testicular Cell Self-Organization. Adv Biosyst, 2020, 4(7).
  9. Ma H#, Zhai J#, Wan H#, Jiang X#, Wang X, Wang L, Xiang Y, He X, Zhao ZA, Zhao B, Zheng P*, Li L*, Wang H*. In vitro culture of cynomolgus monkey embryos beyond early gastrulation. Science, 2019, 366(6467).
  10. Hong LM, Yan L, Xin ZM, Hao J, Liu WJ, Wang SY, Liao SJ, Wang H*, Yang XK*. Protective effects of human umbilical cord mesenchymal stem cell-derived conditioned medium on ovarian damage. J Mol Cell Biol, 2019, 12(5):372-385.
  11. Wang R, Yu RX, Zhu C, Lin HY, Lu XY*, Wang H*. Tubulin detyrosination promotes human trophoblast syncytium formation. J Mol Cell Biol. 2019, 11(11), 967-978.
  12. Ma J, Wu J, Han L, Jiang XX, Yan L, Hao J*, Wang H*. Comparative analysis of mesenchymal stem cells derived from amniotic membrane, umbilical cord, and chorionic plate under serum-free condition. Stem Cell Res Ther, 2018, 10(1), 19.
  13. Liu YW#, Fan XY#, Wang R#, Lu XY#, Dang YL, Wang HY, Lin HY, Zhu C, Ge H, Cross JC*, Wang H*. Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta. Cell Research, 2018, 28(8), 819-832.
  14. Wang Y, Wang H*. Successful derivation of human trophoblast stem cells. Biol Reprod. 2018, 99(2), 271-272.
  15. Jiang XX, Du MR, Li M, Wang H*. Three macrophage subsets are identified in the uterus during early human pregnancy. Cell Mol Immunol, 2018, 15(12), 1027-1037.
  16. Chang WL#, Liu YW#, Dang YL#, Jiang XX, Xu HL, Huang X, Wang YL, Wang H, Zhu C, Xue LQ, Lin HY, Meng WX*, Wang H*. Plac8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration. Development, 2018, 145(2).
  17. Lu XY#, Wang R#, Zhu C, Wang H, Lin HY, Gu Y, Cross JC*, Wang H*. Fine-Tuned and Cell-Cycle-Restricted Expression of Fusogenic Protein Syncytin-2 Maintains Functional Placental Syncytia. Cell Reports, 2017, 21(5), 1150-1159.
  18. Yan L#, Li Y#, Shi Z#, Lu X#, Ma J, Hu B, Jiao J*, Wang H*. The zinc finger E-box-binding homeobox 1 (Zeb1) promotes the conversion of mouse fibroblasts into functional neurons. J Biol Chem, 2017, 292(31), 12959-12970.
  19. Hai T#, Cao C#, Shang H#, Guo W#, Mu Y#, Yang S, Zhang Y, Zheng Q, Zhang T, Wang X, Liu Y, Kong Q, Li K, Wang D, Qi M, Hong Q, Zhang R, Wang X, Jia Q, Wang X, Qin G, Li Y, Luo A, Jin W, Yao J, Huang J, Zhang H, Li M, Xie X, Zheng X, Guo K, Wang Q, Zhang S, Li L, Xie F, Zhang Y, Weng X, Yin Z, Hu K, Cong Y, Zheng P, Zou H, Xin L, Xia J, Ruan J, Li H, Zhao W, Yuan J, Liu Z, Gu W, Li M, Wang Y, Wang H*, Yang S*, Liu Z*, Wei H*, Zhao J*, Zhou Q*, Meng A*. Pilot study of large-scale production of mutant pigs by ENU mutagenesis. Elife, 2017, (6), e26248.
  20. Zhang Y#, Wang Q#, Wang H*, Duan EK*. Uterine Fluid in Pregnancy: A Biological and Clinical Outlook. Trends Mol Med, 2017, 23(7), 604–614.
  21. 王红梅*,杜美蓉*.人类胎盘滋养层细胞的分化与妊娠相关疾病. 生命科学, 2017, 29(1), 15-20.
  22. Liu D#, Mo G#, Tao Y, Wang H*, Liu XJ*. Putrescine supplementation during in vitro maturation of aged mouse oocytes improves the quality of blastocysts. Reprod Fertil Dev, 2017, 29(7), 1392-1400.
  23. Zheng R#, Li Y#, Sun H#, Lu X, Sun BF, Wang R, Cui L, Zhu C, Lin HY*, Wang H. Deep RNA sequencing analysis of syncytialization-related genes during BeWo cell fusion. Reproduction, 2017, 153 (1), 35-48.
  24. Lu X#, He Y#, Zhu C, Wang H, Chen S*, Lin HY*. Twist1 is involved in trophoblast syncytialization by regulating GCM1. Placenta, 2016, 39, 45-54.
  25. Lu X#, Wang Y#, Yan L, Wang L, Li W, Wang H*. Variations in mesenchymal-epithelial transition-related transcription factors during reprogramming of somatic cells from different germ layers into iPSCs. J Genet Genomics, 2016, 43(10), 609-612.
  26. Cui L#, Wang H#, Lu X, Wang R, Zheng R, Li Y, Yang X, Jia WT, Zhao Y, Wang Y, Wang H, Wang YL, Zhu C, Lin HY*, Wang H*. Effects of individually silenced N-glycosylation sites and non-synonymous single-nucleotide polymorphisms on the fusogenic function of human syncytin-2. Cell Adh Migr, 2016, 10(1-2), 39-55.
  27. Wang X#, Cao C#, Huang J#, Yao J, Hai T, Zheng Q, Wang X, Zhang H, Qin G, ChengJ, Wang Y, Yuan Z, Zhou Q, Wang H*, Zhao J*. One-step generation of triplegene-targeted pigs using CRISPR/Cas9 system. Sci Rep, 2016, 6,1-7.
  28. Nie M#, Yu S#, Peng S, Fang Y, Wang H*, Yang X*. miR-23a and miR-27a Promote Human Granulosa Cell Apoptosis by Targeting SMAD5. Biol Reprod, 2015, 93(4), 98, 1-10.
  29. Zhang Q#, Yu S#, Huang X#, Tan Y, Zhu C, Wang Y, Wang H, Lin H, Fu J*, Wang H*. New insights into the function of Cullin 3 in trophoblast invasion and migration. Reproduction, 2015 , 150(2), 139-149.
  30. Lei JH#, Yang XK#, Peng S#, Li Y, Underhill C, Zhu C, Lin HY*, Wang H*, Hammond GL*. Impact of corticosteroid-binding globulin deficiency on pregnancy and neonatal sex. J Clin Endocrinol Metab, 2015, 100(5), 1819-27.
  31. Chang W#, Yang Q#, Zhang H#, Lin HY, Zhou Z, Lu X,, Zhu C, Xue LQ*, Wang H*. Role of placenta-specific protein 1 in trophoblast invasion and migration. Reproduction, 2014, 148(4), 343-352.
  32. Zhou Z#, Wang R#, Yang X, Lu XY, Zhang Q, Wang YL, Wang H, Zhu C, Lin HY*, Wang H*. The cAMP-responsive element binding protein (CREB) transcription factor regulates furin expression during human trophoblast syncytialization. Placenta, 2014, 35(11), 907-18.
  33. Wang R#, Dang YL#, Zheng R, Li Y, Li WW, Lu XY, Wang LJ, Zhu C, Lin HY*, Wang H*. Live cell imaging of in vitro human trophoblast syncytialization. Biol Reprod, 2014, 90(6), 117,1-10 (cover story).
  34. Li W, Liu D, Chang W, Lu XY, Wang YL, Wang H, Zhu C, Lin HY, Zhang Y, Zhou J*, Wang H*. Role of IGF2BP3 in trophoblast cell invasion and migration. Cell Death Dis, 2014, 5, e1025.
  35. Aguilar PS#, Baylies MK#, Fleissner A#, Helming L#, Inoue N#, Podbilewicz B*, Wang H#, Wong M#. Genetic basis of cell–cell fusion mechanisms. Trends Genet, 2013, 29, 427-437 (invited review).
  36. Zhou Z, Zhang Q, Lu XY, Wang R, Wang H, Wang YL, Zhu C, Lin HY*, Wang H*. The proprotein convertases furin is required for trophoblast syncytialization. Cell Death Dis, 2013, 4, e593.
  37. Zhang Q, Chen Q, Lu XY, Zhou Z, Zhang H, Lin HY, Duan E, Zhu C, Tan Y*, Wang H*. CUL1 promotes trophoblast cell invasion at the maternal-fetal interface. Cell Death Dis, 2013, 4, e502.
  38. Yang X, Wang Q, Gao Z, Zhou Z, Peng S, Chang WL, Lin HY, Zhang W*, Wang H*. Proprotein convertases furin regulates apoptosis and proliferation of granulosa cells in the rat ovary. PLoS ONE, 2013, 8, e50479.
  39. Lin HY*, Underhill C, Lei JH, Helander-Claesson A, Lee HY, Gardill BR, Muller YA, Wang H*, Hammond GL*. High frequency of SERPINA6 polymorphisms that reduce plasma corticosteroid-binding globulin activity in Chinese subjects. J Clin Endocrinol Metab, 2012, 97, E678-E686.
  40. Zhao KQ, Lin HY*, Zhu C, Yang X, Wang H*. Maternal Smad3 deficiency compromises decidualization in mice. J Cell Biochem, 2012, 113, 3266-3275.
  41. Wu L, Zhou HH, Lin HY, Qi JG, Zhu C, Gao ZY*, Wang H*. Circulating microRNAs are elevated in plasma from severe pre-eclamptic pregnancies. Reproduction, 2012, 143, 389-397.
  42. Yang XK, Zhou Y, Peng S, Wu L, Lin HY, Wang SY*, Wang H*. Differentially expressed plasma microRNAs in premature ovarian failure patients and the potential regulatory function of mir-23a in granulosa cell apoptosis. Reproduction, 2012, 144, 235-244.
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