Researchers Engineer A Novel Sustainable Karyotype In Mice [2022-08-26]
Evolutionary chromosomal changes may take a million years in nature, but researchers are now reporting a novel technique enabling programmable chromosome fusion that has successfully produced mice with genetic changes that occur on a million-year evolutionary scale in the laboratory. The result may provide critical insight into how rearrangements of chromosomes – the tidy packages of organized genes, provided in equal number from each parent, which align and trade or blend traits to produce offspring – influence evoluti......
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Old Mice, Young Milieu: Understanding How Aged Stem Cells Are Revitalized for Systemic Rejuvenation [2022-05-30]
Aging is a process of systemic degeneration involving a variety of tissues and organs in the whole body and is characterized by gradual reduction of regenerative ability and functional decline. In trying to understand the aging process, and more importantly, in pursuit to reverse it, scientists have developed a technique called heterochronic parabiosis (HP), which surgically connects the circulatory systems of a young and old animal, thus providing a unique paradigm for evaluating how tissues and organs respond to the opp......
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Increase in Chromatin Entropy Drives Cellular Aging, Say Researchers [2022-05-30]
At the center of every cell, highly organized chromatin encodes the program of life with just one set of genes. This is possible because different genes are activated at different stages of life while remaining silent otherwise. Some genes for previous stage of life are buried deep at the nuclear periphery, while some manage to escape from repression....
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APOE destabilizes heterochromatin and drives senescence [2022-03-29]
Prof. Guang-hui Liu and his colleagues from the Institute of Zoology and the Beijing Institute of Genomics, Chinese Academy of Sciences, have collaborated to reveal a novel role of APOE in destabilizing heterochromatin and driving senescence in human stem cells, which was published in Nature Aging on March 28th, 2022....
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Researchers reveal a new role of circadian protein BMAL1 in antagonizing aging in primates [2022-03-16]
Circadian rhythms regulate sleep-wake cycles, metabolism, immune function, and reproduction in mammals. These processes are coordinated by the circadian clock, a biochemical oscillator that integrates physiological input signals with distinct oscillatory phases to regulate rhythms in organismal physiology, behavior, and metabolism. Accumulating evidence indicates that aging in mammals is intricately linked with alterations in circadian rhythms. However, whether and how the circadian machinery directly regulates stem cell ......
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Researchers identify an endogenous metabolite that promotes multiple tissue regeneration and delays aging [2022-02-07]
Regeneration is an important process of rejuvenating or replacing damaged, diseased, or aged tissues. Regenerative capacity declines with evolution and age. For example, salamanders in lower animals have the complete regenerative capacity in limbs, while in most mammals including humans, limited regeneration and functional recovery capabilities reside in young tissues and decline with age. To date, the molecular mechanism underlying the declined regenerative capacity with evolution and age remains poorly understood. Unlik......
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Developmental Cell | De novo generation of macrophage from placenta-derived hemogenic endothelium [2021-06-30]
On June 30, 2021，Professors Feng Liu (from Institute of Zoology, Chinese Academy of Sciences), Jing-Dong J. Han (from Peaking university), Hongmei Wang (from Institute of Zoology, Chinese Academy of Sciences) and Berthold Gottgens (from University of Cambridge) collaborate on a paper entitled “De novo generation of macrophage from placenta-derived hemogenic endothelium” in Developmental Cell journal. This work identifies and experimentally validates that a CD44+ subpopulation of placental endothelial cells (ECs) exhibi......
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Tick tock in the brain: Scientists provide molecular insights into primate hippocampal aging [2021-05-31]
Deep inside our brain is a region called the hippocampus. It plays a crucial role in learning and memory, and its progressive deterioration with age is functionally linked to a variety of human neurodegenerative diseases. But what drives it down the path of aging?...
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Researchers reveal the roles of protein O-GlcNAcylation in modulating human placental trophoblast differentiation [2021-02-25]
O-linked β-N-acetylglucosamine (O-GlcNAc) is a reversible and ubiquitous post-translational modification in eukaryotic cells, which are extensively involved in a wide range of cellular processes. There has been evidence suggesting the involvement of O-GlcNAcylation in embryonic development or fetal health, whereas the underlying mechanisms remain illusive....
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Scientists develop a new gene therapy strategy for delaying aging [2021-01-07]
How many aging-promoting genes are there in the human genome? What are the molecular mechanisms by which these genes regulate aging? Can gene therapy alleviate individual aging? Recently, the researchers from the Chinese Academy of Sciences have shed new light on the regulation of aging....
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