Self-control of HGF regulation on human trophoblast cell invasion via enhancing c-Met receptor shedding by ADAM10 and ADAM17. [2013-08-25]
Research group led byProf. Yan-ling wang discovered that HGF could negatively self-control its regulatory effect on trophoblast cell invasion via enhancing proteolysis of its receptor. This study also showed that unbalanced HGF self-control by pathological conditions such as oxidative stress could lead to impeded placentation in relevance to preeclampsia. These results were recently published in The Journal Of Clinical Endocrinology & Metabolism....
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High Frequency of SERPINA6 Polymorphisms that Reduce Plasma Corticosteroid-Binding Globulin Activity in Chinese Subjects [2013-08-23]
Dr. Hongmei WANG’s group discovered four nonsynonymous SNPs in SERPINA6 gene encoding corticosteroid-binding globulin (CBG): CBG R64Q, CBG R64W, CBG A51V and CBG E102G. The CBG A51V variant has a surprisingly high frequency of 1:37, and plasma CBG levels in individuals heterozygous for this variant are ~50% lower than normal. In vitro biochemistry studies showed that CBG A51V bound steroid normally but its production/secretion was severely impaired....
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