Water Channel-dependent excessive uterinefluid impairs embryo implantation [2014-11-18]
In mammalian species, embryo implantation is the threshold for pregnancy establishment, the abnormality of which accounts for ~75% of human pregnancy loss. Abnormal preimplantation hormonal environment is a common cause for defective embryo implantation, usually attributed to the changed endometrium receptivity. Here, a research group lead by Prof. EnkuiDuan at institute of Zoology, Chinese Academy of Sciences, showed that the abnormal preimplantation hormonal environment also disrupt intrauterine fluid homeostasis that c......
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Embryo-uterine orientation at implantation requires uterine RBPJ signaling [2014-07-02]
Rodent blastocysts show remarkably consistent embryonic orientation with respect to the uterine structure, an orientation established at initial implantation which blueprints the direction of future embryo-uterine axis. However, despite this interesting phenomenon having been discovered more than 100 years (since 1894), there have been few molecular mechanisms found responsible for this trait....
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Integrative Proteomic and Transcriptomic Analyses Reveal Multiple Post-transcriptional Regulatory Mechanisms of Mouse Spermatogenesis [2014-01-27]
Dr.Chunsheng Han’s group in SKLRB collaborated with Dr. Fuquan Yang’s team in the Key Laboratory of Protein and Peptide Pharmaceuticals & Laboratory of Proteomics, Institute of Biophysics, CAS in examining protein expression during mouse spermatogenesis using iTRAQ technology—an up-to-date high throughput quantitative proteomic strategy—coupled with in-depth bioinformatics analysis. Their integrative proteomic and transcriptomic analyses have revealed multiple post-transcriptional regulatory mechanisms of mouse sperma......
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Fragile X Premutation RNA is Sufficient to Cause Primary Ovarian Insufficiency in Mice [2013-12-17]
Research group led by Prof. Dahua Chen created and characterized a mouse model carrying the human FMR1 premutation allele and show that FMR1 premutation RNA can cause a phenotype mimicking human “remature menopause” or “premature ovarian failure” (POF), the phenotype includes a reduction in the number of growing follicles in ovaries which is sufficient to impair female fertility, and alterations of selective serum hormone levels, including FSH, LH, and 17β-estradiol. The researchers also show that the FMR1 premutatio......
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High levels of activin A detected in preeclamptic placenta induce trophoblast cell apoptosis by promoting nodal signaling [2013-10-23]
Research group led by Prof. Yan-ling wang discovered that Plasma and placental productions of Activin A were significantly higher in preeclamptic patients when compared with normal pregnant subjects in a Chinese Han population. They found that abnormally high level of Activin A cause trophoblast cell apoptosis through activation of Nodal signaling. These results were recently published in The Journal Of Clinical Endocrinology & Metabolism....
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Self-control of HGF regulation on human trophoblast cell invasion via enhancing c-Met receptor shedding by ADAM10 and ADAM17. [2013-08-25]
Research group led byProf. Yan-ling wang discovered that HGF could negatively self-control its regulatory effect on trophoblast cell invasion via enhancing proteolysis of its receptor. This study also showed that unbalanced HGF self-control by pathological conditions such as oxidative stress could lead to impeded placentation in relevance to preeclampsia. These results were recently published in The Journal Of Clinical Endocrinology & Metabolism....
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High Frequency of SERPINA6 Polymorphisms that Reduce Plasma Corticosteroid-Binding Globulin Activity in Chinese Subjects [2013-08-23]
Dr. Hongmei WANG’s group discovered four nonsynonymous SNPs in SERPINA6 gene encoding corticosteroid-binding globulin (CBG): CBG R64Q, CBG R64W, CBG A51V and CBG E102G. The CBG A51V variant has a surprisingly high frequency of 1:37, and plasma CBG levels in individuals heterozygous for this variant are ~50% lower than normal. In vitro biochemistry studies showed that CBG A51V bound steroid normally but its production/secretion was severely impaired....
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